Biomics

Cytochrome P450 is an enzyme involved in the phase 1 metabolism of xenobiotics, toxins, endogenous hormones, and drugs. This study examines the population genetic aspects of the distribution of the polymorphic variant rs1065852 of the CYP2D6 gene in Finno-Ugric populations. The study of the CYP2D6 gene in Finno-Ugric populations of Russia is of paramount importance for Russian pharmacogenetics, as the genetic heterogeneity of these groups leads to significant differences in the frequencies of pharmacogenetic markers. This necessitates a differentiated approach to personalized therapy and precludes the extrapolation of averaged European data to the indigenous peoples of the Russian Federation. The study involved 329 presumably healthy individuals from five Finno-Ugric populations across the Russian Federation. Genotyping of the polymorphic variant was performed using TaqMan real-time PCR technology. The studied populations demonstrate significant variability and form a clear intraregional gradient, and overall, they are close to other European groups but differ statistically significantly from East Asian populations.

Finno-Ugric populations, CYP2D6, cytochrome P450, xenobiotics

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