Biomics

The article is devoted to the development of the first Russian sequencer for massive parallel DNA sequencing, the Nanophore SPS. The sequencer was conceived as a domestic alternative to the MiSeq sequencer, which is the most widely used sequencer on the world market, manufactured by the American company Illumina, which has sufficient performance to decode the complete genomes of small organisms – bacteria, viruses, fungi, as well as to decode a large number of samples for groups of genes of interest to researchers. This versatility as well as low cost of analysis (compared to really genome–wide high-throughput sequencers) have led to the great popularity of MiSeq devices. The principle of operation of the Nanophore SPS and MiSeq devices is based on the technology of sequencing by synthesis with fluorescence signal detection, the basic elements of which were developed by Soviet and Russian scientists in the 90s of the last century.

massive parallel DNA sequencing, sequencing by synthesis, fluorescent sequencing, reaction cell

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