Biomics

This review gives a detailed description of the life path of the founder of genetics, Gregor Mendel, who forever entered the pleiad of the most significant personalities in the history of mankind with his peas experiments. Now all biologists know the "Mendel's laws" and the famous trait inheritance a ratio of 3:1. The development of modern DNA sequencing technologies allowed to identify genes of the four of the seven divergent traits studied by Mendel and their localization on chromosomes. The remaining three traits may be encoded by several genes and it is unclear what Mendel used to control specific phenotypes. Unfortunately, the other objects chosen by Mendel and, in particular, the hawkweeds showed the opposite result to the peas due to the apomictic reproduction. Mendel's laws cannot apply to them in principle, but at his time no one knew this yet. In addition, Mendel's introduction of mathematics into biology was so revolutionary that it was misunderstood by his colleagues. Only one scientist, our fellow countryman I.F. Schmalhausen, saw the importance of the results obtained by Mendel, mentioning his 1866 article in the dissertation in 1874. He noted that the method of presenting botanical results in the form of formulas deserves further development. It took more than three decades before the rediscovery of Mendel's laws, accomplished in 1900 almost simultaneously and independently by three scientists - G. de Vries, K. Correns and E. Cermak. Reasoning about certain material carriers, Mendel, in fact, predicted the existence of units of heredity in the form of genes. He demonstrated the binary nature of inherited traits, providing evidence of the sufficiency of one pollen grain for fertilization of an egg. On the basis of experiments with dioecious plants he put forward a hypothesis about the genetic determination of sex. But Mendel's main merit is that his pioneering work gave a very powerful impetus to the further development of this area of research. His works are significant not only for the plant science, since the laws he discovered are applicable to all sexually reproducing organisms. Since Mendel's working notes have not been preserved, and very few articles have been published by him, many of his achievements, including breakthrough ones, are known from the letters he sent to the botanist K. Nageli. In these letters he outlined the results of his research on crossing various plants, but Nageli didn’t pay much attention to the results, focusing only on the hawkweeds. On the bicentennial anniversary of Mendel's birth, his complete genome was sequenced. Bioinformatic analysis of his genome made it possible to discover pathogenic variants of genes that could lead to some diseases, including those manifested in his youth. This review also pays attention to the formation of Mendel as a scientist and the period of his life when he was still Johann. 

Gregor Mendel, Johann Mendel, Mendel's laws, peas, hawkweed, crossing, dominant trait, recessive trait, segregation, gene, genome, sequencing

1. Armstead I, Donnison I, Aubry S, Harper J, Hörtensteiner S, James C, Mani J, Moffet M, Ougham H, Roberts L, Thomas A, Weeden N, Thomas H, King I. Cross-species identification of Mendel's I locus. Science. 2007. V.315(5808). P.73. doi: 10.1126/science.1132912

2. Bailey L.H. Cross-breeding and hybridizing. The philosophy of the crossing of plants considered with reference to their improvement under cultivation // New York. 1892. 44 P.

3. Bateson W. Hybridisation and cross-breeding as a method of scientific investigation // Journal of the Royal Horticultural Society. 1900. V. 24. P.59-66.

4. Bateson W. Mendel's principles of heredity. A defense with a translation of Mendel's original papers on hybridisation. Cambridge University Press. 1902. 212 P.

5. Baymiev Al.Kh., Kuluev A.R., Matniyazov R.T., Garafutdinov R.R., Bayimiev An.Kh., Gimalov F.R., Chemeris D.A., Kuluev B.R., Chemeris A.V. The variety of quantitative estimates of the DNA content in plant nuclei and their dispersion, some terms and concepts (genome, C-value, pangenome). Biomics. 2022. V.14(1). P. 79-100. doi: 10.31301/2221-6197.bmcs.2022-6 (In Russian)

6. Berry A, Browne J. Mendel and Darwin // Proc Natl Acad Sci USA. 2022. V.119(30). e2122144119. doi: 10.1073/pnas.2122144119 

7. Bhattacharyya MK, Smith AM, Ellis TH, Hedley C, Martin C. The wrinkled-seed character of pea described by Mendel is caused by a transposon-like insertion in a gene encoding starch-branching enzyme // Cell. 1990. V.60(1). P.115-122. doi: 10.1016/0092-
8674(90)90721-p

8. Borodin I.P. Ocherki po voprosam oplodotvorenija v rastitel'nom carstve. I. // Mir Bozhiy. 1903. № 4. S.257-272. [Essays on fertilization in the vegetable kingdom. I.] (In Russian)

9. Borodin I.P. Ocherki po voprosam oplodotvorenija v rastitel'nom carstve. II. // Mir Bozhiy. 1903a. № 11. S.199-210. [Essays on fertilization in the vegetable kingdom. II.] (In Russian)

10. Borodin I.P. Ocherki po voprosam oplodotvorenija v rastitel'nom carstve. III. // Mir Bozhiy. 1903b. № 12. S.255-274. [Essays on fertilization in the vegetable kingdom. III.] (In Russian)

11. Byrne J., Dahm R. Friedrich Miescher and the 150th anniversary of the discovery of DNA. Biomics. 2019. V.11(3). P. 249-258. DOI: 10.31301/2221-6197.bmcs.2019-23

12. Chemeris A.V., Aminev F.G., Garafutdinov R.R., Anisimov V.A., SagitovA.M., Khusnutdinova E.K., Sakhabutdinova A.R., Chemeris D.A., Mihaylenko K.I. DNK-kriminalistika. M.: Nauka. 2022. 466 S. [DNA criminalistics] (In Russian)

13. Chemeris A.V., Garafutdinov R.R., Sakhabutdinova A.R., Morozov R.A., Matniyazov R.T., Gerashchenkov G.A., Kuluev B.R., Baymiev An.Kh., Baymiev Al.Kh., Chemeris D.A. Did Neanderthals interbreed en masse with Cro-Magnons? (From a paleodilettantish point of view but taking into account the data of whole genome sequencing of modern and ancient DNA specimens as well as knowledge of the technologies used for this). Biomics. 2022. V.14(1). P. 156-179. DOI: 10.31301/2221-6197.bmcs.2022-12 (In Russian)

14. Chocholová E., Drozdová E., Fialová D. et al., Metagenomic and proteomic analysis of dental calculus of abbot Gregor Johann Mendel Folia Mendeliana. 2022. V.58(1). P.57-61.

15. Correns C. Untersuchungen über die Xenien bei Zea Mays // Berichte der Deutschen Botanischen mGesellschaft. 1899. V.17(10). P. 410-417.

16. Correns C. G.Mendel's Regel über das Verhalten der Nachkommenschaft der Rassenbastarde // Berichte der Deutschen Botanischen Gesellschaft. 1900. V.18. P.158-168.

17. Correns C. Gregor Mendels “Versuche über pflanzenhybriden und die Bestätigung ihrer Ergebnis durch die neuesten Untersuchungen // Bot. Zeitung. 1900a. No. 15. P.229-238.

18. Correns C. Gregor Mendels briefe an Carl Nägeli 1866 – 1873 // 1905. 79 P. 19. de Vries H. Hybridising of monstrosities // Journal of the Royal Horticultural Society. 1900. P.69-75.

20. de Vries H. On the use of transparent parchment paper bags for artificial fertilization // Journal of the Royal Horticultural Society. 1900. P.266-268.

21. de Vries H. Sur la loi de disjonction des hybrides // Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences. 1900. V.130. P.845-847.

22. de Vries H. Das Spaltungsgesetz der Bastarde. // Ber. Deutsch. Bot. Ges. 1900. V.18. P.83-90. 23. de Vries H. Ueber erbungleiche Kreuzungen // Ber. Deutsch. Bot. Ges. 1900. V.18. P.435-441.

24. Dolezel J, Greilhuber J. Nuclear genome size: are we getting closer? Cytometry A. 2010 Jul;77(7):635-42. doi: 10.1002/cyto.a.20915

25. Drozdová E., Fialová D., Chocholová E. et al. Body remains of abbot Gregor Johann Mendel // Folia Mendeliana. 2022. V.58(1). P.37-54.

26. Eichling C.W. I talked with Mendel // Journal of Heredity. 1942. V.33(7). P.243–246. doi: 10.1093/oxfordjournals.jhered.a105181

27. Ellis THN, van Dijk PJ. Mendel's terminology and notation reveal his understanding of genetics // Hereditas. 2023. V.160(1). P.16. doi: 10.1186/s41065-023-00276-x

28. Ellis THN, Hofer JMI, Swain MT, van Dijk PJ. Mendel's pea crosses: varieties, traits and statistics // Hereditas. 2019. V.156. P.33. doi: 10.1186/s41065-019-0111-y

29. Ellis TH, Hofer JM, Timmerman-Vaughan GM, Coyne CJ, Hellens RP. Mendel, 150 years on // Trends Plant Sci. 2011. V.16(11). P.590-596. doi: 10.1016/j.tplants.2011.06.006

30. Fairbanks DJ. Demystifying the mythical Mendel: a biographical review // Heredity (Edinb). 2022. V.129(1). P.4-11. doi: 10.1038/s41437-022-00526-0

31. Fairbanks DJ, Abbott S. Darwin's Influence on Mendel: Evidence from a New Translation of Mendel's Paper // Genetics. 2016. V.204(2). P.401-405. doi: 10.1534/genetics.116.194613

32. Fialová D., Drozdová E., Chocholová E et al. Mutidisciplinary approach to identification of Gregor Johann Mendel’s skeletal remains // Folia Mendeliana. 2022. V.58(1). P.29-36.

33. Filipchenko Ju.A. Frensis Gal'ton i Gregor Mendel'. Serija: Biograficheskaja biblioteka. M., Gosudarstvennoe izdatel'stvo. 1925. 86 S. [Francis Galton and Gregor Mendel. Series: Biographical Library] (In Russian)

34. Fisher R.A. Has Mendel's work been rediscovered? // Annals of Science. 1936. V.1(2). P. 115-137. DOI: 10.1080/00033793600200111

35. Frolov I.T., Pastushnyj S.A. Mendel', mendelizm i dialektika // M. Mysl'. 1972. 230 S. [Mendel, mendelism and dialectics] (In Russian)

36. Gaissinovich A.E. Pervoe izlozhenie raboty G. Mendelja v Rossii (I.F. Shmal'gauzen, 1874) // Bjull. Moskovskogo obshh-va ispytatelej prirody. 1965. T.70(4). S.22-24. [The first exposition of G. Mendel's work in Russia (I.F. Schmalhausen, 1874)] (In Russian)

37. Gaisinovich A.E. Zarozhdenie i razvitie genetiki // M. Nauka. 1988. 424 S. [The origin and development of genetics] (In Russian)

38. Galton D. Did Darwin read Mendel? Q. J. Med. 2009. V.102(8). P.587-589. doi: 10.1093/qjmed/hcp024

39. Garafutdinov R.R., Chemeris A.V. "Russian traces" in early nucleic acids research. Biomics. 2019. V.11(3). P. 266-281. DOI: 10.31301/2221-6197.bmcs.2019-25 (In Russian)

40. Gedda L. Novant'anni delle leggi mendeliane, l865-l955. Rome. 1956. 494 P.

41. Gedda L., Parisi P. Editorial: Gregor Mendel and twins // Twin Research and Human Genetics. 1985. V.34(3-4). P. 121-124. doi: 10.1017/S0001566000004645

42. Gerashchenkov G.A., Garafutdinov R.R., Baymiev An.Kh., Kuluev B.R., Baymiev Al.Kh., Chemeris A.V. The two greatest discoveries of two centuries - the nuclein and the double helix of DNA. Biomics. 2019. V.11(3). P. 259-265. DOI: 10.31301/2221-6197.bmcs.2019-24 (In Russian)

43. Gustafsson A. The life of Gregor Johann Mendel--tragic or not? // Hereditas. 1969. V.62(1). P.239-258. doi: 10.1111/j.1601-5223.1969.tb02232.x

44. Hanson H.C. The Mendel tradition in Brno, Czechoslovakia // Agricultural History. 1948. V.22(3). P.205-208.

45. Hartl DL. Gregor Johann Mendel: From peasant to priest, pedagogue, and prelate // Proc Natl Acad Sci USA. 2022. V.119(30). e2121953119. doi: 10.1073/pnas.2121953119

46. Hartl D.L., Orel V. What did Gregor Mendel think he discovered? // Genetics. 1992. V.131(2). P.245-253. doi: 10.1093/genetics/131.2.245

47. Hellens RP, Moreau C, Lin-Wang K, Schwinn KE, Thomson SJ, Fiers MW, Frew TJ, Murray SR, Hofer JM, Jacobs JM, Davies KM, Allan AC, Bendahmane A, Coyne CJ, Timmerman-Vaughan GM, Ellis TH. Identification of Mendel's white flower character // PLoS One. 2010 Oct 11;5(10):e13230. doi: 10.1371/journal.pone.0013230 

48. Henig R.M. The Monk in the Garden. The Lost and Found Genius of Gregor Mendel, the Father of Genetics. 2000. 280 P.

49. Iltis A. Gregor Mendel’s autobiography // J. Hered. 1954. V.45(5). P. 231-234. doi: 10.1093/oxfordjournals.jhered.a106480

50. Iltis H. Gregor Mendels Leben. Springer, Berlin, Heidelberg. 1924. 197 P. doi: 10.1007/978-3-662-36954-8_1

51. Iltis H. Gregor Mendel and His Work // Scientific Monthly. 1943. V. 56(5). P. 414-423.

52. Jackson B.D. Guide to the literature of botany; being a classified selection of botanical works, including nearly 6000 titles not given in Pritzel’s ‘Thesaurus’. London. 1881. 577 P.

53. Kennedy SR, Schmitt MW, Fox EJ, Kohrn BF, Salk JJ, Ahn EH, Prindle MJ, Kuong KJ, Shen JC, Risques RA, Loeb LA. Detecting ultralow-frequency mutations by Duplex Sequencing // Nat Protoc. 2014. V.9(11). P.2586-2606. doi: 10.1038/nprot.2014.170

54. Klein J., Klein N. Solitude of a Humble Genius - Gregor Johann Mendel: Volume 1. Formative Years // Springer. 2013. 407 P. doi: 10.1007/978-3-642-35254-6 55. Koltsov N.K. Genealogija Ch.Darvina i F.Gal'tona // Russkij evgenicheskij zhurnal. 1922. T.1(1). S. 64-73. (reprint - Priroda. 2012. №10. S.64-70) [Genealogy of Ch.Darwin and F.Galton] (In Russian)

56. Kreplak J, Madoui MA, Cápal P. et al. A reference genome for pea provides insight into legume genome evolution // Nat Genet. 2019. V.51(9). P.1411-1422. doi: 10.1038/s41588-019-0480-1

57. Kuluev B.R., Baymiev An.Kh., Gerashchenkov G.A., Yunusbaev U.B., Garafutdinov R.R., Alekseev Ya.I., Baymiev Al.Kh., Chemeris A.V. One hundred years of haploid genomes. Now time comes for diploid genomes. Biomics. 2020. Vol. 12(4). P. 411-434. DOI: 10.31301/2221-6197.bmcs.2020-33 (In Russian)

58. Larsson B. Mendel citerad i svensk text 1872 // Botaniska Notiser. 1915. P.35-38.

59. Laxton T. Observations on the variations effected by crossing in the color and character of the seed of peas // Report of the International Horticultural Exhibition and Botanical Congress. 1866. P. 156.

60. Laxton T. Notes on some changes and variations in the offspring of cross-fertilized peas // Journal of the Royal Horticultural Society. 1872. V.3. P.10–14.

61. Lester DR, Ross JJ, Davies PJ, Reid JB. Mendel's stem length gene (Le) encodes a gibberellin 3 beta-hydroxylase // Plant Cell. 1997. V.9(8). P.1435-1443. doi: 10.1105/tpc.9.8.1435

62. Liu Y. Darwin and Mendel: who was the pioneer of genetics? // Rivista di Biologia. 2005. V.98(2). P.305-322.

63. Lujie Y., Zha F., Sekerak J., Zhao X., Han J., Sun K., Zhang H. On the bicentennial of Mendel’s birth, attempting to recover Mendel’s inheritance principles with Mendel’s eyes // Folia Mendeliana. 2022. V.58(2). P.79-90.

64. Martin DN, Proebsting WM, Hedden P. Mendel's dwarfing gene: cDNAs from the Le alleles and function of the expressed proteins // Proc Natl Acad Sci USA. 1997. V.94(16). P.8907-8911. doi: 10.1073/pnas.94.16.8907

65. Matalová A., Matalová E. Gregor Mendel – The Scientist. Based on Primary Sources 1822-1884. Springer. 2022. 304 P. doi: 10.1007/978-3-030-98923-1

66. Mendel G. Versuche über Pflanzen-Hybriden. Verhandlungen des Naturforschenden Vereins zu Brünn. 1866. V.4. P. 3-47

67. Mendel G., 1870. Ueber einige aus künstlicher Befruchtung gewonnenen Hieracium-Bastarde. Verhandlungen des naturforschenden Vereines in Brünn 8: 26–31.

68. Mendel G. Gregor Mendel's letters to Carl Nägeli, 1866-1873 // Genetics. 1950. V.35. P.1-29. 69. Mendel G. Opyty nad rastitel'nymi gibridami. M. 1935. [Experiments on plant hybrids] (In Russian)

70. Mendel G. Opyty nad rastitel'nymi gibridami. M. 1965. [Experiments on plant hybrids] (In Russian)

71. Mielewczik M., Francis D.P., Studer B., Simunek M.V., Hossfeld U. Die Rezeption von Gregor Mendels Hybridisierungsversuchen im 19. Jahrhundert – Eine bio-bibliographische Studie // Nova Acta Leopoldina NF. 2017. No. 413. P. 83 –134.

72. Monaghan F, Corcos A. Chi-square and Mendel's experiments: where's the bias? // J Hered. 1985. V.76(4). P.307-309. doi: 10.1093/oxfordjournals.jhered.a110099

73. Monaghan FV, Corcos AF. Reexamination of the fate of Mendel's paper // J Hered. 1987. V.78(2). P.116-118. doi: 10.1093/oxfordjournals.jhered.a110328

74. Mulvihill J., Carda J., Macek M., Genuardi M., Easter C., Fairbanks D., Lindee M.S., Adam V., Dostál O., Sekerák J., Křížová B., Pospíšilová Š. eP434: Celebrating and commemorating the 2022 bicentennial of Mendel’s birth, the exhumation of Mendel's body for archeologic, anthropologic, and genomic research // Genet. Med. 2022. V.24(3). Suppl. S271-S272. doi: 10.1016/j.gim.2022.01.468

75. Nivet C. Une maladie enigmatique dans la vie de Gregor Mendel // Med. Sci. (Paris). 2004. V.20(11). P.1050-1053. doi: 10.1051/medsci/200420111050

76. Novikov Yu.M. Gregor Mendel: my time will come. Vavilovskii Zhurnal. Vavilovskii Zhurnal Genetiki i Selektsii – Vavilov Journal of Genetics and Breeding. 2015;19(1):7-12. DoI 10.18699/VJ15.001

77. Olby R., Gautrey P. Eleven references to Mendel before 1900 // Annals of Science. 1968. V.24(1). P. 7-20. DOI: 10.1080/00033796800200021

78. Orel V. Gregor Mendel: The first geneticist. Oxford University Press. 1996. 376 P.

79. Orel V. The enigma of hybrid constancy in Mendel's Pisum paper perceived by Albert Blomberg in 1872 // Hereditas. 1973. V.73(1). P. 41-43. doi: 10.1111/j.1601-5223.1973.tb01065.x

80. Ostenfeld C.H., Raunkier C. Kastreringsforsog med Hieracium og andre Cichoriee // Botanisk tidsskrift. 1903. V.25. P.409-413.

81. Pardy F., Hynst J., Fialová D., Brzobohatá K., Hejtmánek L., Pospishilová S. Reconstructing the genome of Gregor Johann Mendel using state-of-the-art molecular and bioinformatics tools // Folia Mendeliana. 2022. V.58(1). P.53-60.

82. Price D. Malaja nauka, bol'shaja nauka // Nauka o nauke. M.: Progress. 1966. S.281-384. [Small science, big science] (In Russian)

83. Punnett R. An Early Reference to Mendel's Work // Nature. 1925. V. 116. P. 606. doi: 10.1038/116606a0

84. Reid JB, Ross JJ. Mendel's genes: toward a full molecular characterization // Genetics. 2011. V.189(1). P.3-10. doi: 10.1534/genetics.111.132118

85. Richter FC. Remembering Johann Gregor Mendel: a human, a Catholic priest, an Augustinian monk, and abbot // Mol Genet Genomic Med. 2015. V.3(6). P.483-485. doi: 10.1002/mgg3.186

86. Richter O. Johann Gregor Mendel wie er wirklich war. Neue Beiträge zur Biographie des berühmten Biologen aus Brünns Archiven. Brünn. 1943. 263 P.

87. Roberts H.F. Plant hybridization before Mendel // Princeton, Princeton University Press, 1929. 374 P. doi: 10.5962/bhl.title.4517

88. Rolfe A. Hybridisation viewed from the standpoint of systematic botany// Journal of the Royal Horticultural Society. 1900. V. 24. P.181-202.

89. Saltykova E.S., Chemeris D.A., Vershinina Z.R., Gerashchenkov G.A., Gimalov F.R., Chemeris A.V. The genius of Gregor Mendel and other scientific interests of the father of genetics, besides crossing of peas. Biomics. 2023. V.15(2). P.139-150. DOI: 10.31301/2221-6197.bmcs.2023-14 (In Russian)

90. Sato Y, Morita R, Nishimura M, Yamaguchi H, Kusaba M. Mendel's green cotyledon gene encodes a positive regulator of the chlorophyll-degrading pathway // Proc Natl Acad Sci USA. 2007. V.104(35). P.14169-14174. doi: 10.1073/pnas.0705521104

91. Sekerák J. Mendel’s date of birth // Folia Mendeliana. 2022. V.58(1). P.63-75.

92. Shirasawa K, Sasaki K, Hirakawa H, Isobe S. Genomic region associated with pod color variation in pea (Pisum sativum) // G3 (Bethesda). 2021. V.11(5). jkab081. doi: 10.1093/g3journal/jkab081

93. Shmal'gauzen I.F. O rastitel'nyh pomesjah: Nabljudenija iz Peterburg. flory : Dis. I. Shmal'gauzena, predstavl. v Fiz.-mat. fak. S.-Peterb. un-ta dlja poluchenija step. magistra botaniki. - Sankt-Peterburg :  tip. V. Demakova, 1874. 113 S. [On plant hybrids: Observations from the St. Petersburg flora: I. Schmalhausen's Dissertation] (In Russian)

94. Simunek M.V., Hossfeld U. Mendel’s manuscript of “Versuch über Pflanzenhybriden”: The (never) ending story // Research Project DFG HO2143/8–1, 8-2. 2010.

95. Soudek D. Gregor Mendel and the people around him (commemorative of the centennial of Mendel's death) // Am J Hum Genet. 1984. V.36(3). P.495-498.

96. Spirin A.S. (ed.) Friedrich Miescher. Trudy po biohimii. M. 1985. 318 s. (Friedrich Miescher. Works on biochemistry.) [In Russian]

97. Stankov S.S. Professor Ivan Dorofeevich Chistjakov i ego predshestvenniki v Moskovskom universitete // Bjulleten' Moskovskogo ob-va ispytatelej prirody. Otdel biologicheskij. 1946. T. 51(2). S. 99-109. [Professor Ivan Dorofeevich Chistyakov and his predecessors at the Moscow University] (In Russian)

98. Sussmilch FC, Ross JJ, Reid JB. Mendel: From genes to genome. Plant Physiol. 2022 Nov 28;190(4):2103-2114. doi: 10.1093/plphys/kiac424

99. Sutton W.S. The chromosomes in heredity // Biol. Bull. 1903. V.4. P.231-251.

100. Szybalski W. Professor Alexandr Zawadzki of Lvov university – Gregor Mendel’s mentor and inspirer // Biopolymers and Cells. 2010. V.26(2). P.83-86.

101. Тсhistiakoff I. Matériaux pour servir à l´histoire de la cellule végétale. Memoire 1—3. // Nuovo giornale botanico Italiano. 1874. V.6. P. 70—93, 209—243, 257—319.

102. Trapezov О.V. Mendel: corroboration of the idea of binary trait coding by methods of statistical physics. Vavilovskii Zhurnal Genetiki i Selektsii – Vavilov Journal of Genetics and Breeding. 2015;19(1):27-38. Doi: 10.18699/VJ15.003

103. Trapezov O.V. Povorotnyj moment v nauke o zhivom: ustanovlenie zakonov nasledstvennosti // Filosofija nauki. 2015. №66. S.113-136. DOI: 10.15372/PS20150308 [The turning point in the science of the living: the establishment of the laws of heredity] (In Russian)

104. Tschermak E. Über künstliche Kreuzung bei Pisum sativum // Ber. Deutsch. Bot. Ges. 1900. V.18. P.232-239.

105. van Dijk PJ, Ellis TH. The Full Breadth of Mendel's Genetics // Genetics. 2016. V.204(4). P.1327-1336. doi: 10.1534/genetics.116.196626

106. van Dijk P.J., Ellis T.H.N. Mendel’s journey to Paris and London: Content and significance for the origin of genetics // Folia Mendeliana. 2020. V.56(1-2). P.5-33.

107. van Dijk P.J., Ellis T.H.N. From Gregor Mendel’s 1865-lectures to his 1866-masterpiece // Folia Mendeliana. 2022. V.58(1). P.77-98.

108. van Dijk PJ, Jessop AP, Ellis THN. How did Mendel arrive at his discoveries? // Nat Genet. 2022. V.54(7). P.926-933. doi: 10.1038/s41588-022-01109-9

109. Volodin B.P. Mendel (Vita aeterna) // M., Molodaya gvardiya. 1968. 258 P. (In Russian)

110. Vorzimmer P.J. Darwin and Mendel: The Historical Connection // Isis. 1968. V. 59(1). P. 77-82.

111. Walsh J.B., Marks J. Sequencing the human genome // Nature. 1986. V.322. P. 590. doi: 10.1038/322590a0

112. Weiling F.F. C.Napp und J.G.Mendel Ein Beitrag zur Vorgeschichte der Mendelschen Versuche // Theoret. Appl. Genetics. 1968. V. 38. P. 144–148. doi: 10.1007/BF00933809

113. Weiling F. What about R.A. Fisher's statement of the "too good" data of J.G. Mendel's Pisum paper? // J. Hered. 1986. V.77(4). P.281-283. doi: 10.1093/oxfordjournals.jhered.a110239

114. Weiling F. Historical study: Johann Gregor Mendel 1822-1884 // Am J Med Genet. 1991. V.40(1). P.1-25; discussion 26. doi: 10.1002/ajmg.1320400103 115. White O.E. Studies of Inheritance in Pisum. II. The Present State of Knowledge of Heredity and Variation in Peas // Proceedings of the American Philosophical Society. 1917. V.56(7). P.487-588.

116. Williams G. Unravelling the Double Helix: The Lost Heroes of DNA. Wiedeneld & Nicolson. London. 2019. 494 P.

117. Winkler H. Verbreitung und Ursache der Parthenogenesis im Pflanzen- und Tierreiche. 1920. Jena: Gustav Fischer Verlag. 250 s.

118. Yang T, Liu R, Luo Y et al. Improved pea reference genome and pan-genome highlight genomic features and evolutionary characteristics // Nat Genet. 2022. V.54(10). P.1553-1563. doi: 10.1038/s41588-022-01172-2

119. Zhang H, Zhao X, Zhao F, Han J, Sun K. Mendel's controlled pollination experiments in Mirabilis jalapa confirmed his discovery of the gamete theory of inheritance in Pisum // Hereditas. 2022. V.159(1). P.19. doi: 10.1186/s41065-022-00232-1

120. Zorin EA, Kliukova MS, Afonin AM, Gribchenko ES, Gordon ML, Sulima AS, Zhernakov AI, Kulaeva OA, Romanyuk DA, Kusakin PG, Tsyganova AV, Tsyganov VE, Tikhonovich IA, Zhukov VA. A. variable gene family encoding nodule-specific cysteinerich peptides in pea (Pisum sativum L.). Front Plant Sci. 2022 Sep 14;13:884726. doi: 10.3389/fpls.2022.884726

121. Zubov V.V., Chemeris D.A., Vasilov R.G., Kurochkin V.E., Alekseev Ya.I. Brief history of highthroughput nucleic acid sequencing methods. Biomics. 2021. V.13(1). P. 27-46. DOI: 10.31301/2221-6197.bmcs.2021-4 (In Russian)