Biomics

With the purpose to search for predictors of aging and longevity we studied the pattern of the SOD1 and SOD2 genes polymorphic loci interaction in a sample of residents of the Republic of Bashkortostan, including 1592 individuals in age between 18 and 109 years old. We discovered the reduction of the chances to become the long-liver among carriers of the combination of SOD2*rs4880*TT genotype and SOD1*rs2070424*G allele (OR=0.33, POR=0.02, SF=0.27, PSF=0.046 for elderly people and OR=0.31, POR=0.01, SF=0.28, PSF=0.041 for old seniors), as well as of the SOD2*rs4880*TT and SOD1*rs2070424*GA genotypes combination (OR=0.32, POR=0.01, SF=0.29, PSF=0.043 for the elderly people). The found alleles/genotypes combinations, which associated with the low activity of Cu/ZnSOD and Mn-SOD, have a synergistic pattern of interaction and are unfavorable for the attainment the longevity.

longevity, aging, superoxide dismutase 1, SOD1 gene, superoxide dismutase 2, SOD2 gene, polymorphic marker, synergy factor, association analysis

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