Biomics

С целью поиска предикторов старения и долголетия на выборке жителей Республики Башкортостан, включающей 1592 человека в возрасте от 18 до 109 лет, изучен характер межлокусных взаимодействий генов SOD1 и SOD2. Установлено снижение шансов достижения долголетия среди носителей сочетания генотипа SOD2*rs4880*ТТ и аллеля SOD1*rs2070424*G (OR=0.33, P_OR=0.02, SF=0.27, P_SF=0.046 для лиц пожилого возраста и OR=0.31, P_OR=0.01, SF=0.28, P_SF=0.041 для лиц старческого возраста), а также генотипов SOD2*rs4880*ТТ и SOD1*rs2070424*GA (OR=0.32, P_OR=0.01, SF=0.29, P_SF=0.043 для лиц старческого возраста). Найденные сочетания аллелей/генотипов, ассоциированные с низкой активностью Cu/Zn-SOD и Mn-SOD, имеют синергический характер взаимодействия и неблагоприятны в отношении достижения возраста долголетия.

долголетие, старение, супероксиддисмутаза 1, ген SOD1, супероксиддисмутаза 2, ген SOD2, полиморфный маркер, фактор синергии, анализ ассоциаций

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