Biomics

The renin-angiotensin-aldosterone system plays an important role in the processes responsible for the formation of myocardial infarction (MI). It is involved in the regulation of oxidative stress, in the development of endothelial dysfunction and inflammatory response, in destabilization of atherosclerotic plaque, regulation of vascular tone and circulating blood volume. A significant part of these effects are mediated through the molecules of the JAK/STAT signaling pathway and the nuclear factor NF-kappa-B1. The aim of this study was to analyze associations of MI with combinations of alleles/genotypes by polymorphic markers rs310216*JAK1, rs12693591*STAT1, rs3212780*JAK3, rs2293152*STAT3, rs28362491*NFKB1, rs4762*AGT, rs2368564*REN, rs4343*ACE, rs5186*AGTR1, rs1800875*CMA1, rs4491175*LINC02748, rs1799998*CYP11B2, rs2285666*ACE2, rs1403543*AGTR2. The material for the study was the DNA of patients with onset MI at the age of 45 years (144) and the control group (152). All study participants were male, ethnically Russian. Combinations were searched using the APSampler software. The selection criteria for combinations were: a P value

polymorphic markers, myocardial infarction

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