Biomics

Over the two decades that have passed since the development of loop amplification (Loop AMPlification, LAMP), that carry out to detect specific nucleic acid under isothermal conditions, it has undergone quite a lot of improvements. This review presents data represented methodological bases of about a hundred variations of the LAMP, classified according to the methods of detecting both target DNA products (lamplicons) and by-products (pyrophosphate and protons), considering the specificity of the processes, and according to the purpose of certain LAMP options and implementation, including microfluidics. Particular attention is paid to quantitative LAMP amplification and promising digital LAMP. The prospects for the development of the method are presented.

LAMP, isothermal loop amplification, reverse-transcriptional loop amplification, RT-LAMP, lamplicon, DNA, RNA, diagnostics

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