Петлевая LAMP амплификация нуклеиновых кислот. I. Два десятилетия развития и совершенствования
06.08.2021
Авторы:
Название:
Петлевая LAMP амплификация нуклеиновых кислот. I. Два десятилетия развития и совершенствования
Страницы:
176-226
За два десятилетия, прошедших после появления петлевой амплификации (Loop AMPlification, LAMP), проводящейся в изотермических условиях для обнаружения специфичных фрагментов нуклеиновых кислот, она претерпела довольно много усовершенствований. В настоящем обзоре приведены данные, отражающие методические основы около сотни вариаций метода LAMP, сгруппированных по способам детекции как целевых ДНК-продуктов − лампликонов, так и побочных, представленных пирофосфатом и протонами, с учетом специфичности процессов; по предназначению тех или иных вариантов LAMP; по способам ее проведения, включая микрофлуидику. Определенное внимание уделено количественной LAMP-амплификации и ее перспективному варианту − цифровой LAMP. Представлены перспективы развития метода.
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