Biomics

Myocardial infarction (MI) is a multifactorial polygenic disease. It develops because of the complex interaction between many environmental and genetic factors. In this investigation, we have studied associations of MI and rs1042034 (gene APOB), rs4420638 (gene APOC1) rs2070424 (gene SOD1) и rs662 (ген PON1) in an ethnically homogeneous group. The material for analysis was DNA samples of patients (365 men) with onset of MI at the age of 30 to 60 years and 292 essentially healthy men of the control group. The study revealed markers of increased risk of MI: SOD1*A/A, for men under 46 years of age (P=0.029, OR=1.96), APOC1*A/G (P=0.03, OR=2.01), for men over 48 years of age, and APOB*C/C (P=0.031OR=1.8).

genetic polymorphism, myocardial infarction, lipoproteides, oxidative stress

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