eISSN: 2221-6197 DOI: 10.31301/2221-6197

Inulin: natural sources, features of metabolism in plants and practical application

Year: 2020

Pages: 57-79

Number: Volume 12, issue 1

Type: scientific article

Summary:

Inulin is a polymer consisting of several fructose residues (10 to 36) in the form of furanose. This polysaccharide is the second most abundant carbohydrate after starch in plants and is most characteristic on representatives of the families Asteraceae and Campanulaceae. This review is devoted to the consideration of natural sources of inulin, the characteristics of metabolism, the functions of inulin in plants and the practical use of inulin. The highest inulin content is found in the roots of plants of the Asteraceae family, such as Arctium sp., Cichorium sp., Taraxacum sp., Smallanthus sp., Inula sp. and others. On an industrial scale, inulin is obtained from chicory, Jerusalem artichoke and agave. Inulin synthesis in plants is regulated by several fructosyltransferase enzymes, the most important of which are sucrose:sucrose-1- fructosyltransferase (1-SST) and fructan:fructan-1-fructosyltransferase (1-FFT). The genes of these enzymes are used as a target in genetic engineering and genome editing in order to change the inulin content in plants. Inulin is widely used as a biologically active food supplement as a prebiotic. The consumption of inulin with food provides the creation of optimal conditions for the growth and development of normal intestinal microflora; increased resistance of the digestive system to bacterial and viral infections. There is a great demand for inulin in Russia, however, this dietary fiber is still not produced in our country. In this regard, the launch of plants for the production of inulin from natural materials is very promising for Russia.

Keywords:

prebiotic, fructooligosaccharides, sucrose-1-fructosyltransferase, fructan-1-fructosyltransferase, chicory, Jerusalem artichoke, elecampane

References:

1.Aksel'rod D.M. Kul'tura krymsagyza [Culture of krym-saghyz] // V knige Kauchuk i kauchukonosy. Pod red. M.M. Il'ina. 1953. P. 237–315. In Russian.

2.Atlas lekarstvennykh rasteniy SSSR [Atlas of medicinal plants of the USSR] / Gl. red. N. V. Tsitsin. M.: Medgiz, 1962. P. 50-52. In Russian.

3.Babayeva Ye.YU., Zvereva V.I., Semkina O.A. Soderzhaniye fruktozanov inulinopodobnogo tipa v podzemnykh organakh ekhinatsei purpurnoy i produktakh ikh pererabotki [The content of inulinlike fructosans in the underground organs of purple coneflower and products of their processing]. Khimiko-farmatsevticheskiy zhurnal. 2018. V. 52. No.7. P. 26–29. In Russian.

4.Bol'shaya sovetskaya entsiklopediya [The Great Soviet Encyclopedia], izd. 3-ye, M., Sovetskaya entsiklopediya. 1972. V.10. P. 344. In Russian.

5.Barkhatova T.V., Nazarenko M.N., Kozhukhova M.A., Khripko I.A. Obtaining and identification of inulin from jerusalem artichoke (Helianthus tuberosus) tubers. Foods and Raw Materials. 2015. V. 3. No. 2. P. 13–22.

6.Barszcz M., Taciak M., Tuśnio A., Święch E., Skomiał J. Dose-dependent effects of two inulin types differing in chain length on the small intestinal morphology, contractility and proinflammatory cytokine gene expression in piglets. Arch Anim Nutr. 2019. P. 1-14. doi: 10.1080/1745039X.2019.1697140

7.Becerril-Alarcon Y., Campos-Gomez S., ValdezAndrade J.J., Campos-Gomez K.A., ReyesBarretero D.Y., Benítez Arciniega A.D., ValdesRamos R., Soto-Pina A.E. Inulin supplementation reduces systolic blood pressure in women with breast cancer undergoing neoadjuvant chemotherapy. Cardiovasc Ther. 2019. 5707150. doi: 10.1155/2019/5707150

8.Boeckner L.S.; Schnepf M.I., Tungland B.C. Inulin: a review of nutritional and health implications. Advances in Food and Nutrition Research. 2001. V. 43. P. 1–63.

9.Chi L., Khan I., Lin Z., Zhang J., Lee M.Y.S., Leong W., Hsiao W.L.W., Zheng Y. Fructooligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model. Phytomedicine. 2019. V. 67:153157. doi: 10.1016/j.phymed.2019.153157

10. Delgado G., Tamashiro W. M., Maróstica M.J. Yacon (Smallanthus sonchifolius): a functional food. Plant Foods for Human Nutritio. V. 68. 2013. P. 222–228

11. Deng P., Hoffman J.B., Petriello M.C., Wang C.Y., Li X.S., Kraemer M.P. Morris A.J., Hennig B. Dietary inulin decreases circulating ceramides by suppressing neutral sphingomyelinase expression and activity in mice. J Lipid Res. 2020. V. 61. P. 45–53. doi: 10.1194/jlr.RA119000346

12. Diedhiou C., Gaudet D., Liang Y., Sun J., Lu Z. Carbohydrate profiling in seeds and seedlings of transgenic triticale modified in the expression of sucrose:sucrose-1-fructosyltransferase (1-SST) and sucrose:fructan-6-fructosyltransferase (6-SFT). Journal of Bioscience and Bioengineering. 2012. V. 114. No. 4. P. 371–378.

13. Dobrange E., Peshev D., Loedolff B., Van den Ende W. Fructans as immunomodulatory and antiviral agents: the case of Echinacea. Biomolecules. 2019. V. 9(10). pii: E615. doi: 10.3390/biom9100615

14. Filippov D.I. Kul'tura koksagyza (Culture of kok-saghyz). V knige Kauchuk i kauchukonosy. Pod red. M.M. Il'ina. 1953. P. 173–219. In Russian.

15. Gao T., Jiao Y., Liu Y., Li T., Wang Z., Wang D. Protective effects of konjac and inulin extracts on type 1 and type 2 diabetes. J Diabetes Res. 2019. 3872182. doi: 10.1155/2019/3872182

16. Garshin M.V., Kartuha A.I., Kuluev B. R. Taraxacum kok-saghyz: cultivation features and perspectives of introduction to modern production. Biomics. 2016. V. 8(4). P. 323–333. In Russian.

17. Garshin M.V., Kuluev B.R. Krym-saghyz: features of the plant, prospect of cultivation and selections (review). Agrarnaya Rossiya (Agrarian Russia). 2018. No. 4. P. 40–48. (In Russian).

18. Gokhale S., Bhaduri A. Provitamin D3 modulation through prebiotics supplementation: simulation based assessment. Sci Rep. 2019. V. 9(1):19267. doi: 10.1038/s41598-019-55699-2

19. Guaragni A., Boiago M.M., Bottari N.B., Morsch V.M., Lopes T.F., Schafer da Silva A. Feed supplementation with inulin on broiler performance and meat quality challenged with Clostridium perfringens: Infection and prebiotic impacts. Microb
Pathog. 2019. V. 139:103889. doi: 10.1016/j.micpath.2019.103889

20. Haiping D., Zhao A., Qi W., Yang X., Ren D. Supplementation of inulin with various degree of polymerization ameliorates liver injury and gut microbiota dysbiosis in high fat-fed obese mice. J Agric Food Chem. 2020. doi: 10.1021/acs.jafc.9b06571

21. Henrissat, B. A classification of glycosyl hydrolases based on amino acid sequence similarities. Biochem. J. 1991. V. 280. P. 309–316.

22. Hellwege E.M., Czapla S., Jahnke A., Willmitzer L., Heyer A.G. Transgenic potato (Solanum tuberosum) tubers synthesize the full spectrum of inulin molecules naturally occurring in globe artichoke (Cynara scolymus) roots. Proc Natl Acad Sci U S A. 2000. V. 97. P. 8699–8704.

23. Hisano H., Kanazawa A., Kawakami A., Yoshida M., Shimamoto Y., & Yamada, T. (2004). Transgenic perennial ryegrass plants expressing wheat fructosyltransferase genes accumulate increased amounts of fructan and acquire increased tolerance on a cellular level to freezing. Plant Science. V. 167. P. 861–868. doi: 10.1016/j.plantsci.2004.05.037

24. Hughes S.R., Qureshi N., López-Núñez J.C., Jones M.A., Jarodsky J.M., Galindo-Leva L.A., Lindquist M.R. Utilization of inulin-containing waste in industrial fermentations to produce biofuels and bio-based chemicals. World Journal of Microbiology & Biotechnology. 2017. V. 33. doi:10.1007/s11274-017-2241

25. Iaffalando B., Zhang Y., Cornish K. CRISPR/Cas9 genome editing of rubber producing dandelion Taraxacum kok-saghyz using Agrobacterium rhizogenes without selection. Ind. Crops Prod. 2016. V. 89. P. 356–362. doi: 0.1016/j.indcrop.2016.05.029

26. Igolkin G.I. Kauchukonosnyye kuzinii [Rubberbearing cousins] // V knige Kauchuk i kauchukonosy. Pod red. M.M. Il'ina. 1953. P. 637–642. In Russian.

27. Karayeva I.T., Khmelevskaya A.V., Cherchesova S.K. Issledovaniye osnovnykh klassov biologicheski aktivnykh veshchestv devyasila vysokogo Inula helenium), proizrastayushchego v Respublike Severnaya Osetiya–Alaniya [The study of the main classes of biologically active substances of elecampane high (Inula helenium), growing in the Republic of North Ossetia-Alania]. Izvestiya Gorskogo gosudarstvennogo agrarnogo universiteta. 2016. No. 53. P. 147–149. In Russian.

28. Kathy R. Inulin and oligofructose: what are they? The Journal of Nutrition. 1999. V. 129. P. 1402–1406.

29. Kawakami A., Sato Y., Yoshida M. Genetic engineering of rice capable of synthesizing fructans and enhancing chilling tolerance. Journal of Experimental Botany. 2008. V. 59. No. 4. P. 793–802.

30. Kerepesi I., Galiba G., Banyai E. Osmotic and salt stresses induced differential alteration in watersoluble carbohydrate content in wheat seedlings. J Agric Food Chem. 1998. V. 46. P. 5347–354.

31. Kuluev B.R., Garafutdinov R.R., Maksimov I.V., Sagitov A.M., Chemeris D.A., Knyazev A.V., Vershinina Z.R., Baymiev An.K., Muldashev A.A., Baymiev Al.K. Chemeris A.V. Natural rubber, its sources and components. Biomics. 2017a. V. 7. No. 4. P. 224–283. In Russian.

32. Kuluev B.R., Kartuha A.I., Knyazev A.V., Fateryga A.F., Chemeris A.V. Growing experience of Taraxacum hybernum (Asteraceae). Rastitelnye resursy. 2017b. V. 53. No. 4. P. 543–554. In Russian.

33. Kuluev B.R., Berezhneva Z.A., Chemeris A.V. Hydroponic and aeroponic growing of Russian dandelion Taraxacum kok-saghyz Rodin. Biomics. 2017. V. 9. No. 2. P. 96–100. In Russian.

34. Kuluev B.R., Fateryga A.V., Kuluev A.R., Mikhaylova E.V., Chemeris A.V. The molecular genetic study of krim-saghyz (Taraxacum hybernum Steven) using SSR, RAPD and ISSR markers. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2018. V. 22. P. 102–107. doi: 10.18699/VJ18.337. In Russian.

35. Kuluev B. R., Muldashev A. A., Minchenkov N. D., Chemeris A. V. Searching for potential rubberbearing plants in the flora of the Republic of Bashkortostan. Rastitelnye resursy. 2019a. V. 55. No. 3. P. 317–333. In Russian.

36. Kuluev B.R., Shvets D.Yu., Golovanov Ya., Probatova N.S. Thladiantha dubia (Cucurbitaceae) in the Republic of Bashkortostan as a dangerous weed with high invasive potential. Russian Journal of Biological Invasions. 2019b. V. 10. P. 160–170. doi: 10.1134/S2075111719020097

37. Kooiker M., Drenth J., Glassop D., C. Lynne McIntyre, TaMYB13-1, a R2R3 MYB transcription factor, regulates the fructan synthetic pathway and contributes to enhanced fructan accumulation in bread wheat. Journal of Experimental Botany. 2013. V. 64. No. 12. P. 3681–3696.

38. Kotov M.I. Krym-sagyz (Taraxacum hybernum Stev.). V knige Kauchuk i kauchukonosy. Pod red. M.M. Il'ina. 1953. P. 220–229. In Russian.

39. Kreuzberger M., Hahnb T., Zibek S., Schiemanna J. Seasonal pattern of biomass and rubber and inulin of wild Russian dandelion (Taraxacum koksaghyz L. Rodin) under experimental field conditions. Europ. J. Agronomy. 2016. V. 80. P. 66–77.

40. Le Bastard Q., Chapelet G., Javaudin F., Lepelletier D., Batard E., Montassier E. The effects of inulin on gut microbial composition: a systematic review of evidence from human studies. Eur J Clin Microbiol Infect Dis. 2019. V. 39. P. 403–413. doi: 10.1007/s10096-019-03721-w

41. Lepine A.F.P., Konstanti P., Borewicz K., Resink J.W., de Wit N.J., Vos P., Smidt H., Mes J.J. Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella typhimurium in piglets. Sci Rep. 2019. V. 9. 18017. doi: 10.1038/s41598-019-54353-1

42. Maroufi A., Karimi M., Mehdikhanlou K., Loose M. Inulin chain length modification using a transgenic approach opening new perspectives for chicory. Biotech. 2018. V. 8:349. P. 1–8.

43. Matasova S.A., Mitina N.A., Ryzhova G.L., Zhuganov D.O., Dychko K.A. Polucheniye sukhogo ekstrakta iz korney devyasila vysokogo i izucheniye yego khimicheskogo sostava [Obtaining a dry extract from the roots of Elecampane high and the study of its chemical composition. Khimiya rastitel'nogo syr'ya. 1999. No. 2. P. 119–123. In Russian.

44. Marschall M., Proctor M.C.F., Smirno N. Carbohydrate composition and invertase activity of the leafy liverwort Porella platyphylla. New Phytol. 1998. V. 138. P. 343–353.

45. Mazraeh R., Azizi-Soleiman F., Jazayeri S.M.H.M., Noori S.M.A. Effect of inulin-type fructans in patients undergoing cancer treatments: A systematic review. Pak J Med Sci. 2019. V. 35. P. 575–580. doi: 10.12669/pjms.35.2.701

46. Mensink M.A., Frijlink H.W., van der Voort Maarschalk K., Hinrichs W.L. Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics. Carbohydr Polym. 2015a. V. 130. P. 405–419. doi: 10.1016/j.carbpol.2015.05.026

47. Mensink M.A., Frijlink H.W., van der Voort Maarschalk K., Hinrichs W.L. Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications. Carbohydr Polym. 2015b. V. 134. 418-428. doi: 10.1016/j.carbpol.2015.08.022

48. Meyer D., Blaauwhoed J.-P. Inulin. In handbook of hydrocolloids (second edition). 2009.

49. Michalska A., Wojdyło A., Brzezowska J., Majerska J., Ciska E. The Influence of inulin on the retention of polyphenolic compounds during the drying of blackcurrant juice. Molecules. 2019. V. 24. pii: E4167. doi: 10.3390/molecules24224167

50. Mikhaylova E.V., Kuluev B.R., Yasybaeva G.R., Chemeris A.V. Creation of Withania somnifera hairy root cultures and estimation of their growth parameters on solid and liquid medium. Yu.A. Ovchinnikov Bulletin of Biotechnology and Physical and Chemical Biology. 2017. V. 13. No. 2. P. 40–45. In Russian.

51. Mikhlin D.M., Akhunbaeva B.O. Fructosans of the roots of kok-saghyz. Biochemistry. 1956. V. 21. No. 2. In Russian.

52. Mitrokhin M.A., Chesnokov N.N., Podgornaya T.P., Shchekochikhina V.A. Tladianta somnitel'naya (Thladiantha dubia Bunge) kak perspektivnaya kul'tura dlya ispol'zovaniya v landshaftnoy arkhitekture i proizvodstva produktov zdorovogo pitaniya [Thladiantha dubia Bunge as a promising culture for use in landscape architecture and the production of healthy food] // Materialy Mezhdunarodnoy nauchno-prakticheskoy konferentsii, posvyashchennoy 85-letiyu so dnya rozhdeniya zasluzhennogo rabotnika vysshey shkoly RF, doktora s.-kh. nauk, professora YU.G. Skripnikova. 2016. P. 194–196. In Russian.

53. Nadezhkina M.S., Sagina O.A. Inulin: svoystva, primeneniye. Mirovoy rynok inulina (Inulin: properties, application. World market of inulin). Modern Science. 2020. No. 1-2. P. 76–80. In Russian.

54. Nazarenko M.N., Barkhatova T.V., Kozhukhova M.A., Khripko I.A., Burlakova E.V. Inulin changes in Jerusalem artichoke tubers during storage. Scientific Journal of KubSAU. 2013. V. 10. No. 94. P. 13-22.

55. Polyanina T.YU., V'yutnova O.M., Novikova I.A. Khozyaystvennoye znacheniye, khimicheskiy sostav i tselebnyye svoystva tsikoriya (Economic value, chemical composition and healing properties of chicory). Izvestiya FNTSO. 2019. No. 2. P. 94–97. In Russian.

56. Post J., van Deenen N., Fricke J., Kowalski N., Wurbs D., Schaller H., Eisenreich W., Huber C., Twyman R.M., Prüfer D., Gronover C.S. Laticiferspecific cis-prenyltransferase silencing affects the rubber, triterpene, and inulin content of Taraxacum brevicorniculatum. Plant Physiol. 2012. V. 158. P. 1406–1417.

57. Puchkova T., Pikhalo D., Karasyova M., About the universal technology of processing Jerusalem artichoke and chicory for inulin all-Russian research institute for starch products. Food systems. 2019. V. 2. No. 2. P. 36–43.

58. Ramirez-Cadavid D.A., Cornish K., Michel F.C. Jr. Taraxacum kok-saghyz (TK): compositional analysis of a feedstock for natural rubber and other bioproducts. Industrial Crops and Products. 2017. V. 107. P. 624–640.

59. Roberfroid M.B. Inulin-type fructans: functional food ingredients. J Nutr. 2007. V. 137. P. 2493S– 2502S. doi: 10.1093/jn/137.11.2493S

60. Roover J., Vandenbranden K., Van Laere A., Van den Ende W. Drought induces fructan synthesis and 1-SST (sucrose:sucrose fructosyltransferase) in roots and leaves of chicory seedlings (Cichorium intybus L.). Planta. 2000. V. 210. P. 808–814.

61. Schroeven L., Lammens1 W., Kawakami A., Yoshida M., Van Laere A., Van den Ende W. Creating S-type characteristics in the F-type enzyme fructan:fructan 1-fructosyltransferase of Triticum aestivum L. Journal of Experimental Botany. 2009. V. 60. No. 13. P. 3687–3696.

62. Shang H., Zhao J., Dong X., Guo Y., Zhang H., Cheng J., Zhou H. Inulin improves the egg production performance and affects the cecum microbiota of laying hens. Int J Biol Macromol. 2019a. pii: S0141-8130(19)37832-8. doi: 10.1016/j.ijbiomac.2019.11.137

63. Shang H., Zhang H., Guo Y., Wu H., Zhang N. Effects of inulin supplementation in laying hens diet on the antioxidant capacity of refrigerated stored eggs. Int J Biol Macromol. 2019b. pii: S0141- 8130(19)33781-X. doi: 10.1016/j.ijbiomac.2019.10.234

64. Shoaib M., Shehzad A., Omar M., Rakha A., Raza H., Sharif H.R., Shakeel A., Ansari A., Niazi S. Inulin: properties, health benefits and food applications. Carbohydr Polym. 2016. V. 147. P. 444–454. doi: 10.1016/j.carbpol.2016.04.020

65. Shvets D.Yu., Kuluev B.R. Thladiantha Dubia: biology, habitat, distribution area and practical application. Reports of the Bashkir University. 2017. V. 2. No. 5. P. 725–735. In Russian.

66. Solovyova A.I., Stepanova A.Yu. Patent 0002691604 "A method of obtaining a root culture of a kok-sagyz dandelion (Taraxacum kok-saghyz Rodin)" from 06/14/2019. In Russian.

67. Song J., Li Q., Everaert N., Liu R., Zheng M., Zhao G., Wen J. Effects of inulin supplementation on intestinal barrier function and immunity in specific pathogen-free chickens with Salmonella infection. J Anim Sci. 2020. pii: skz396. doi: 10.1093/jas/skz396

68. Soromotina T.V. Redkiye ogorodnyye kul'tury ot A do YA.: spravochnik [Rare garden crops from A to Z: reference book] / T.V. Soromotina; M-vo s.- kh. RF, federal'noye gos. byudzhetnoye obrazov. uchrezhdeniye vysshego obrazovaniya «Permskaya gos. s.-kh. akad. im. akad. D.N. Pryanishnikova». – Perm': IPTS «Prokrost"». 2016. 295 pp. In Russian.

69. Stolze A., Wanke A., van Deenen N., Geyer R., Prüfer D., Schulze Gronover C. Development of rubber-enriched dandelion varieties by metabolic engineering of the inulin pathway. Plant Biotechnology Journal. 2017. V. 15. P. 740–753.

70. Sturm A. Invertases. Primary structures, functions, and roles in plant development and sucrose partitioning. Plant Physiol. 1999. V. 121. P. 1–8.

71. Suarez-Gonzalez E.M., Lopez M.G., DelanoFrier, J.P., Gomez-Leyva J.F. Expression of the 1- SST and 1-FFT genes and consequent fructan accumulation in Agave tequilana and A. inaequidens is differentially induced by diverse (a)biotic-stress related elicitors. Journal of Plant Physiology. 2013. V. 171. P. 359-372. doi: 10.1016/j.jplph.2013.08.002

72. Tarasenko N.A. Inulin i oligofruktoza: effektivnost' v kachestve prebioticheskogo volokna dlya konditerskoy promyshlennosti [Inulin and oligofructose: efficacy as a prebiotic fiber for the confectionery industry]. Fundamental'nyye issledovaniya. 2014. No. 9-6. P. 1216–1219. In Russian.

73. Ufimtseva M.G. Ckortsonera (Scorzonera hispanica) kak istochnik inulinsoderzhashchego syr'ya (Scorzonera (Scorzonera hispanica) as a source of inulin-containing raw materials). Agroprodovol'stvennaya politika Rossii. 2018. No.
3. P. 34–37. In Russian.

74. Ulmann M. Wertvolle Kautschukpflanzen des gemaßigten Klimas dargestellt aufgrund sowjetischer Forschungsarbeiten. Berlin (Germany): Akademie-Verlag GmbH. 1951. 562 s.

75. Ustyuzhaninova L.V., Martinson Ye.A. Opredeleniye optimal'nykh parametrov ekstraktsii iz klubney topinambura [Determination of optimal extraction parameters from Jerusalem artichoke tubers]. Sbornik statey XVIII Vserossiyskoy nauchno-prakticheskoy konferentsii v 3 t. Vyatskiy gosudarstvennyy universitet. 2018. P. 204–213. In Russian.

76. Van den Ende W., Van Wonterghem D., Verhaert P., Dewil E., De Loof A., Van Laere A. Purication and characterization of 1-SST, the key enzyme initiating fructan biosynthesis in young chicory roots (Cichorium intybus L.). Physiol Plant. 1996. V. 98. P. 455–466.

77. Van den Ende, Valluru R. Plant fructans in stress environments: emerging concepts and future prospects. J. Exp. Bot. V. 59, 2008. P. 2905–2916

78. Van Laere A., Van den Ende W. Inulin metabolism in dicots: chicory as a model system. Plant, Cell and Environment. 2002. V. 25. P. 803–813. doi: 10.1046/j.1365-3040.2002.00865.x

79. Van Der Meer I.M., Koops A.J., Hakkert J.C., van Tunen A.J. Cloning of the fructan biosynthesis pathway of Jerusalem artichoke. Plant J. 1998. V. 15. P. 489–500.

80. Vergauwen R., Van Laere A. Properties of fructan:fructan 1-fructosyltransferases from chicory and globe thistle, two Asteracean plants storing greatly different types of inulin. Plant Physiol. 2003. V. 133. P. 391–401.

81. V'yutnova O.M. Istoriya i rasprostraneniye kul'tury tsikoriya (History and distribution of chicory culture). Ovoshchi Rossii. 2016. No. 1. P. 52–53. In Russian.

82. V'yutnova O.M., Polyanina T.YU., Novikova I.A. Perspektivnyy obrazets kornevogo tsikoriya (A promising sample of chicory root). Ovoshchi Rossii. 2019. № 6. P. 159–161. In Russian.

83. Wang L., Yang H., Huang H., Zhang C., Zuo H.X., Xu P., Niu Y.M., Wu S.S. Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose-response meta-analysis of 33 randomized controlled trials. J Transl Med. 2019a. V. 17:410. doi: 10.1186/s12967-019-02159-0

84. Wang Z., Zhang X., Zhu L., Yang X., He F., Wang T., Bao T., Lu H., Wang H., Yang S. Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice. Int Immunopharmacol. 2020. V. 78:106062. doi: 10.1016/j.intimp.2019.106062

85. Wang W., Chen D., Yu B., Huang Z., Luo Y., Zheng P., Mao X., Yu J., Luo J., He J. Effect of dietary inulin supplementation on growth performance, carcass traits, and meat quality in growing-finishing pigs. Animals (Basel). 2019b. V. 9. pii: E840. doi: 10.3390/ani9100840

86. Watson A.W., Houghton D., Avery P.J., Stewart C., Vaughan E.E., Meyer P.D., de Bos Kuil M.J.J., Weijs P.J.M., Brandt K. Changes in stool frequency following chicory inulin consumption, and effects on stool consistency, quality of life and composition of gut microbiota. Food Hydrocoll. 2019. V. 96. P. 688–698. doi: 10.1016/j.foodhyd.2019.06.006

87. Wong J.M., de Souza R., Kendall C.W., Emam A., Jenkins D.J. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol. 2006. V. 40. P. 235–243.

88. Yan M.R., Welch R., Rush E.C., Xiang X., Wang X. A Sustainable wholesome foodstuff; health effects and potential dietotherapy applications of yacon. Nutrients. 2019. V. 11. pii: E2632. doi: 10.3390/nu11112632

89. Yuniastuti A. Iswari R.S. Isolation and identification of inulin and FOS from Dioscorea esculenta. UNNES International Conference on Research Innovation and Commercialization. 2018. V. 2019. P. 41-46. doi: 10.18502/kss.v3i18.4696

90. Zeaiter Z., Regonesi M.E., Cavini S., Labra M., Sello G., Di Gennaro P. Extraction and characterization of inulin-type fructans from artichoke wastes and their effect on the growth of intestinal bacteria associated with health. Biomed Res Int. 2019. 1083952. doi: 10.1155/2019/1083952.

91. Zhuchkova M.A., Skripnikov S.G. Topinambur - rasteniye XXI veka (Jerusalem artichoke is a plant of the 21st century). Ovoshchi Rossii. 2017. No. 1. P. 31–33. In Russian.

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eISSN: 2221-6197 DOI: 10.31301/2221-6197