Biomics

Multiple Sclerosis (MS) is considered as the autoimmune neurodegenerative multifactorial disease caused by complex interaction of numerous polymorphic genes and environmental factors. The aim of this study was to analyze the associations between MS and polymorphic DNA markers of autoimmune diseases rs2744148 (LOC107984898), rs744166 (STAT3 gene), rs1800693 (TNFRSF1A gene), rs2069762 (IL2 gene) and rs6897932 (IL7R gene), identified in Genome Wide Association Studies. Study group included unrelated MS patients (N=87) aged between 15 and 67 years and control group individuals (N=122) aged between 18 and 63 years. Both patients and controls belonged to the ethnic group of Bashkirs. Result of the analysis of associations between the studied polymorphic DNA markers and MS have shown that for women the IL2*G/G genotype is associated with the decreased risk of MS (P=0.02, OR = 0.28 95% CI 0.1 – 0.81). Furthermore, using APSampler algorithm, we identified the combinations of alleles associated with the increased risk of MS development varying by gender, which most  commonly included rs2744148*G, STAT3*T, TNFRSF1A*G, IL2*T, IL7R*T alleles.

multiple sclerosis, DNA markers, association study, GWAS, APSampler

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