Biomics

Over the last years the transplant treatment of HIV/AIDS based on transplantation of HIV-resistant hematopoietic stem cells with ∆32 mutation in CCR5 gene attracts a lot of interest. The homozygous carriers of this mutation reach about 1-2% of total population in Russia. For their search the development of specialized HIV-resistant hematopoietic cells donor registry and cord blood units on the basis of already existing registries and cord blood banks is needed.

In the presented review the history of the first successful transplant treatment of HIV/AIDS (“The Berlin patient”) and the development of this kind of treatment in USA and Germany were discussed. The risks obstructed to widespread implementation of this approach in Russia were described. The information about number of potential donors of hematopoietic stem cells in Russian registries and about the number of cord blood units in cord blood banks was presented. The approximate cost of search and HLA-typing of ∆32 mutation carriers was calculated. And the prospects of cost-cutting of HLA-typing using modern high throughput DNA sequencing were considerated.

HIV, AIDS, HIV-resistance, CCR5∆32, HSC transplantation, NGS, high throughput sequencing, HLA typing, hematopoietic stem cell donorship, bone marrow donor registries

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