Biomics

The widespread use of chlorpyrifos increases the relevance of its toxic properties. Clearly, most studies take into account the consequences of a single high dose intake by the body. Whereas for humans and animals, there is a significantly higher risk of receiving low doses of chlorpyrifos over a long period of time. The insecticide can enter the body in various ways, including with proper food and animal products. The thrust mass is an integrated indicator of the physiological state of the body, and its dynamics can serve as a sensitive marker of chronic intoxication. Contradictory data on the effect of chlorpyrifos on the mass of tremors are described in the literature: some investigations indicate an increase in everything due to the accumulation of adipose tissue, while others show the opposite results. The study was conducted on the basis of the St. Petersburg State Pediatric Medical University. The aim of the study was to detect the effects of chronic exposure to chlorpyrifos on the dynamics of mass pushing white laboratory rats. Control and experimental groups of animals were formed. To simulate a chronic poisoning, a sensitive group of animals received chlorpyrifos orally at a dose of 40 mg/kg for two months. The body weight of the animals was measured over a period of two months, with an interval of 10 days. The data obtained indicate the suppression of sets of masses pushed into a reasonable group of animals. Such results can preferably be explained by metabolic changes in the resolution of prolonged toxic stress. These data confirm that the dynamics of the body weight is an informative integrated indicator for chronic toxicity.

laboratory rats, organophosphorus compounds, chlorpyrifos, chronic poisoning, body weight

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