Biomics

Although this article is more like scientific fantastic, the creation of “talking” dogs through genetic engineering cannot be ruled out in the near future. The transcription factor FOXP2, which is responsible for communication abilities and articulate speech in humans, may become a key target. This protein is very conservative and in addition to some differences in the polyglutamine area differs in various organisms by single amino acid substitutions. FOXP2 of humans and its closest relative chimpanzees differ by two amino acids, while humans and dogs differ by only one amino acid (p.N303T), caused by a single nucleotide substitution, which can be corrected using CRISPR/Cas genome editing technology. Attempts to create talking dogs can make a significant contribution to the development of research on the effects of normal and defective human FOXP2 genes. In this case, dogs may serve as a more suitable model object for this kind of research. Of greatest interest in terms of giving the ability to talk to dogs are breeds of companion dogs, as well as decorative breeds due to their greater demand and accordingly commercial attractiveness. The barking of dogs, which is practically not used by their wolf ancestors, can be considered a kind of independent attempt by dogs to establish communication with humans during domestication. Undoubtedly, the appearance of talking dogs will entail the development of new bioethical principles. 

dog, Canis familiaris, DNA, genome, transgenic dog, “speaking” dog, CRISPR/Cas genome editing

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