Biomics

Brief characteristics of CRISPR loci which found in approximately half of the bacteria and most archaea are given. Their typical organization, an important element of which serve CRISPR-cassette that contains unique spacers alternating with identical direct repeats are shown. Specialized search programs for CRISPR-cassettes in the sequenced genomes of microorganisms and metagenomic data by identifying of repeating sections in them are briefly considered. The web pages of these programs and their purpose and capabilities are shown in tabular form. Databases for CRISPR-loci showing their web addresses are described. Almost all available literature on the matter and relevant Internet resources are analyzed.

CRISPR, CRISPR/Cas system, CRISPR-locus, CRISPR-cassette, spacer, quasi-tandem repeat, protospacer, software, web-resource, database

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