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  9. Разнообразие методов детекции полиморфных нуклеотидов в известных снипах. III. Аллель-специфичная ПЦР

Разнообразие методов детекции полиморфных нуклеотидов в известных снипах. III. Аллель-специфичная ПЦР

Год: 2022

Страницы: 32-51

Номер: Том 14, № 1

Тип: научная статья

DOI: https://doi.org/10.31301/2221-6197.bmcs.2022-2

Рубрика: Статьи

Авторы: Чемерис Дмитрий Алексеевич, Гарафутдинов Равиль Ринатович, Кулуев Азат Разяпович, Сахабутдинова Ассоль Рафиковна, Кулуев Булат Разяпович, Чемерис Алексей Викторович

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Аннотация:

Замены одиночных нуклеотидов (SNP) составляют наибольшую долю полиморфизма ДНК практически любых организмов, включая человека, и оказывают заметное влияние на их жизненный статус. Детекция уже известных полиморфных нуклеотидов (SNP-типирование) приобретает важное значение, чем объясняется чрезвычайно большое разнообразие существующих методов анализа SNP. Одним из наиболее широко применяемых подходов является аллель-специфичная ПЦР (АС- ПЦР) с праймерами, характеризующимися различиями в строении и обусловленной этим способностью дискриминировать полиморфные нуклеотиды в ДНК. АС-ПЦР реализована во множестве вариантов (около полусотни), кратко рассмотренных в данном обзоре.

Ключевые слова:

НК, однонуклеотидный полиморфизм, ОНП, снип, ПЦР, аллель-специфичная ПЦР, АС-ПЦР, SNP-типирование

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