Biomics

Сделаны предположения о тенденциях развития полногеномного и полнотранскриптомного секвенирования будущего и местах его проведения. Описано потенциальное влияние методов секвенирования нуклеиновых кислот (геномов и транскриптомов) 4-го и 5-го поколений на выявление полиморфных состояний геномов организмов разных уровней генетической сложности, включая человека. Дана характеристика различных типов полиморфизма ДНК человека и эволюция их исследований. Уделено некоторое внимание размерам геномов и так называемому парадоксу C-value. Сделан прогноз о количестве полностью секвенированных геномов и транскриптомов к 2030 году с распределением по годам. Изложен один из способов генотипирования штаммов бактерий с присвоением последним уникальных генетических штрих- кодов на основе метода КМРФ (концевого мечения рестриктазных фрагментов ДНК). Рассмотрен метод присвоения различным организмам ДНК-штрих-кодов на основе полиморфизма гена цитохром С оксидазы. Цитированная литература охватывает почти столетний период.

ДНК, РНК, белок, геном, секвенирование, ПЦР, гель-электрофорез, КМРФ, ДНК-чипы, олигонуклеотиды, геномика, транскриптомика, метиломика, GWAS, CNV, VNTR, STR, SNP, снипы

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