Biomics

Показано место молекулярной биологии среди других современных биологических дисциплин и довольно кратко прослежено ее развитие с 80-х годов XX века по настоящее время. Проведено сравнение описательной, экспериментальной и теоретической биологической науки. Сопоставлены ряд ранее сделанных прогнозов до 2000 г. и на первое десятилетие XXI века. Основное внимание уделено методам секвенирования ДНК, полногеномному секвенированию, а также амплификации нуклеиновых кислот с помощью различных вариантов ПЦР, олигонуклеотидному синтезу, ДНК-чипам. Отражено методическое состояние и соответствующее ему приборное оснащение физико-химической биологии. Приведена информация о полностью секвенированных геномах различных организмов по состоянию на середину 2013 г. Высказано предположение, что появление в будущем нового сверхвысокопроизводительного и, вместе с тем, дешевого метода секвенирования коренным образом изменит всю биологическую науку, так как это не сможет сделать ни одна другая новая технология. Цитированная литература охватывает более чем столетний период - с 1912 по 2013 гг.

ДНК, РНК, белок, геном, секвенирование, ПЦР, гель-электрофорез, ДНК-чипы, олигонуклеотиды, геномика, транскриптомика, метиломика, протеомика, биоинформатика, биомика

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